ISBE.NL @ O|2, First Floor, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands, EU

Call Fast: +31 20 5987230

Welcome to ISBE.NL

The Netherlands' arm of ISBE-Light (the Infrastructure for Systems Biology Europe), ISBE@NL, has started its operation 1 September 2016, with its first service provision:

Make Me My Model 

4M 4U: Non modellers can obtain (assistance with) the making of a computational model of their  biological system

If interested, please e-mail the executive director  Alexey Kolodkin (

In March 2018 ISBE.NL has extended to include the groups of Ilja Arts (Maastricht), Natal van Riel (Eindhoven) and Vitor Martins dos Santos (Wageningen) and their expertise

Modelling expertise offered as a service in ISBE.NL:

 Systems Biology Amsterdam (Alexey Kolodkin, Hans Westerhoff et al): precise kinetic models of metabolism and signal transduction; metabolic control analysis, hierarchical regulation analysis, non-equilibrium dynamics, statistical mechanics, enzyme kinetics, flux balance analysis.  Energy and carbohydrate metabolism in Archaea, Bacteria and human;  ammonium assimilation in Bacteria; differential network-based drug design; cancer metabolic rewiring; cell cycle; genome wide metabolic map and inborn errors of metabolism; epigenetics.

 Wageningen University (Vitor Martins dos Santos et al): meta-genomics -transcriptomics and –proteomics; analyses of complex communities of the GIT; genome-scale modelling and engineering; reverse engineering and network inference; chassis-circuit interactions; model-driven experimental circuit design; multivariate statistical analysis; defining growth media; vaccine production; drug target identification TB; cell factories; bio-remediation

 Eindhoven (Natal van Riel et al): Data-driven kinetic and physiological modelling of human metabolism and its regulatory systems; dynamic modelling; parameter estimation; uncertainty quantification; Metabolic Syndrome; liver diseases; diabetes; skeletal muscle energy metabolism,

 University of Maastricht (Ilja Arts et al): Systems medicine

Questions, Answers, Comments, Complaints and Suggestions

[Background picture shows William of Occam (1285- 1349), who was the first to liberate science from non-rational issues by formulating the law of parsimony –  an heuristic method consisting of shaving away” unnecessary assumptions or cutting apart two similar theories: “One should not postulate (pose) more things without necessity” (Pluralitas non est ponenda sine necessitate, Latin). Nowadays the law of parsimony for systems biology will sound differently (“binocular principle”). Instead of shaving “pluralitas” away, one should be interested in discovering and distinguishing those “pluralitates” that are vital and in taking them into account. Then the law of parsimony will become also the law of completeness: “One should not remove things without necessity” (pluralitas non est eliminanda sine necessitate, Latin). The plurality includes more than 300 genes and the networking of their products.]

CORBEL open call has been closed...

Thanks to those who applied!

New call is coming soon!

ISBE.NL is part of ISBElight which also offers model and data stewardship services through JWS-online and its component FAIRDOM

Who we are at ISBE.NL (Amsterdam)

 and ISBE.UK-MCISB (Manchester):

Systems Biologists eager to make models for you:

Alexey Kolodkin (executive director): Dynamic modelling of signalling and Parkinson's disease

Ablikim Abulikemu: Systems Immunology

Stefania Astrologo: Modelling noise, tumor cell heterogeneity and drug resistance

Matteo Barberis:  Cell cycling

Zahid Hassan: Systems ecology and bioremediation

Thierry Mondeel: Map making, Flux Balance Analysis, Microbial Energetics

Samrina Rehman: Functional genomics' data analysis

 Yanfei Zhang (UvA): Extremophile energetics

Ewelina Weglarz-Tomczak (UvA): Modelling for ISBE.NL and personalized medicine

Jacky Snoep: data stewardship, modelling, malaria, HIV

Hans V. Westerhoff: Control and regulation analysis, thermodynamics, modelling


ISBE-scientists at the other ISBE nodes in Europe

ISBE.NL is largely based at SystemsBiologyAmsterdam.NL

Contact us

We like to answer your questions and to make systems biology models for you

ISBE.NL@ the two collaborating Amsterdam Universities (University of Amsterdam and Vrije Universiteit) Joint UvA-VUA campus

 +31 20 - 5987230